The aim of this research is to study Ni2+ supported on hydroxyapatite-core-shell magnetic γ-
Fe2O3 nanoparticles (γ-Fe2O3@HAp-Ni2+) as a green and recyclable catalyst for the Biginelli
reaction under solvent-free conditions. One-pot multi-component condensation of 1,3-dicarbonyl
compounds, urea and aldehydes at 80 oC affords the corresponding compounds in high yields
and in short reaction times using γ-Fe2O3@HAp-Ni2+. The catalyst can be readily isolated using
an external magnet and no obvious loss of activity was observed when the catalyst was reused in
seven consecutive runs. The mean size and the surface morphology of the nanoparticles were
characterized by transmission electron microscopy, scanning electron microscope, vibrating
sample magnetometry, X-ray powder diffraction and Fourier transform infrared techniques.
