Very recently, the employment of nanocrystalline metal oxides as catalysts in organic synthesis has attracted much attention. Nanocatalysts in general and nano metal oxides in particular, despite having a greater chemical reactivity, suffer from inappropriate physical forms that make their practical applications often unfeasible or at least formidable [1].
Imidazo[1,2-a]pyridines show wide range of biological activities such as antibacterial, antiinflammatory, analgesic, antipyretic, hypnoselective, and anxioselective activities [2]. Some methods have been reported for the synthesis of imidazo[1,2-a]pyridine derivatives [3-4]. However, these procedures require the use of toxic organic solvents, expensive catalysts and tedious workup.
