Investigation of the Effect of Vitamin E Function on Liver Injuries in Wistar Rats

Vitamin E can provide a good antioxidant, according to scientific evidence regarding the pharmacology and high-dose medicinal properties of the liver. Vitamin E transmission occurs through the residues of chylomicrons, intermediatedensity, low- or high-density lipoproteins. The liver directs various forms of vitamin E either to the catabolic pathway or to various lipoproteins through unknown mechanisms.Materials and Methods: Adult male and female Wistar rats weighing 222 g were used, pregnant rats were randomly divided into six experimental groups and from day zero of gestation to day 2 after birth of vitamin E and oil. Received by gavage. And a number ofoffspring were euthanized on day 3 after anesthesia and liver for histopathological examination and measurement ofantioxidant activity, MDA, GPX, SOD and placed at -80 ° C. Microtomes were cut to about 1 micron in thickness and stained by H&E method and studied by light microscopy. Results: There was a significant reduction in oxidative enzymes MDA in vitamin E group compared to control group(P <0.5). GPX levels also increased significantly compared to controls (P <0.5). And histopathology showed a significantincrease in the number of hepatocytes at doses of 122, 222 , 400 and vitamin E (P <0.5).Discussion: Vitamin E has a favorable effect on oxidative stress and reduces cell toxicity. It also reduces the damage tolobules and hepatocytes, as well as maintaining stability and integrity of liver cells

Liver, Vitamin E, Antioxidant, Rat, Histopathology