Application of carbon nanotubes for stem cells differentiation as a nanoscaffold with biopolymers

Stem cells are able to differentiate into types of tissues. Invivo studies and clinical experiments are shown that stem cells are limitation in regeneration of dead tissues and degenerative organs. Researchers can control stem cells differentiation according to density of cells and cellular matrix by development of techniques for making microenvironments in micro and nano scales, CNTs have excellent mechanical strength and conductive electrical and they are able to maintain structural scaffolds integrity during cell growth. They can also mimic three dimensional structures of extracellular matrix proteins. CNT conductive ability does not change in environmental conditions against to polymers and they can interact with neuron cells in invivo, respectively. Nowadays, polymers such as polylactic acid are used in engineering tissues. PLLA have biocompatible and biodegradation properties. Results showed that specificity of nanoscaffold were affected by PLLA concentration. Herein, amount of nanoscaffold porosity was increased with high PLLA concentration and cells were greatly attached to scaffolds. Thus, using nanotubes accompany to biopolymers are influenced in attachment, survival and stem cells differentiation to types of cells.

Carbon nanotube (CNT), Stem cell, Nanoscaffold, Polylactic acid (PLLA).