We present a 24-year-old female referred with non-healing wound of a few days duration on
anterior aspect of her right foreleg. Biopsy of the wound was reported to be pyoderma gangrenosum on
pathologic report. Further work up of the patient for high grade fever and occasional leukopenias revealed the
diagnosis of cyclic neutropenia. Treatment with granulocyte colony-stimulating factor (G-CSF) resulted in
patient's neutrophil counts correction and dramatic improvement in healing of her lower extremity wound.
