چکیده :

Abnormalities in cholesterol and homocysteine metabolism have been reported in thyroid diseases. Since elevated levels of both parameters are involved in atherogenesis, and thyroid hormones are modulators of oxidative stress. In this study, the correlation between serum levels of cholesterol, and homocysteine, and oxidative stress was assessed in patients with thyroid dysfunction. Materials and Methods: A total of 60 patients with thyroid dysfunction (30 with hypothyroidism and 30 with hyperthyroidism) were included in this study. Thirty apparently healthy sex and age matched individuals were selected as control group. The mean age of hypothyroid, hyperthyroid and control groups were 43±7.7, 39±12 and 40±7.9 years, respectively. Serum levels of homocysteine were measured by HPLC and those of thyroid hormones (T3, T4, T3 R. uptake and TSH) by radioimmunoassay techniques. Levels of total antioxidant capacity, lipid profiles and creatinine were determined by standard methods in Cobas Mira Autoanalyzer. Results: The mean±SD levels of homocysteine in hyperthyroid, hypothyroid and control groups were 7.79±1.44, 17.09±6.93 and 8.08±1.92

کلید واژگان :

Hyperhomocysteinemia, Oxidative stress, Thyroid dysfunction, Serum lipids, Antioxidant capacity



ارزش ریالی : 400000 ریال
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