Platelets were considered as hemostatic cells. Platelets are small discoid blood cells produce in bone marrow. There are many intracellular structures inside the platelets containing glycogen, lysosomes, and three types of granules including: alpha-granules; dense-granules; and lysosomes. Alpha-granules, when platelets become degranulated, release hundreds of proteins those are composed of an array of chemotactic and mitogenic growth factors, adhesion molecules, hemostatic factors and different cytokines. Platelet growth factors including: PDGF, TGF-β, FGF, ILGF1, ILGF2, VEGF, EGF, Il8, KGF and CTGF. Platelet-rich plasma is a volume of autogenous plasma which has a platelet concentration. PRP with 1,000,000 platelets/μl can provide by concentration of platelets in a 5-ml volume of plasma, is the working definition of PRP today. Thrombin act as platelet activator, induce immediate PGF release of the PRP. It is used in medicine for a ‘‘scarless repair’’, or regeneration in situ. Use of PRP as a regenerative medicine has affordability, availability, and minimally invasive properties. The applications of PRP in medicine are for wound healing bone healing, tendon healing, ligament healing, cartilage healing, joints healing, muscle healing and nerves healing. We conclude that the use of platelet-rich plasma in different tissues can result different outcome and more studies are needed. The main purpose of this paper is to evaluate and summarize the applications of PRP in the regenerative literature, with particular focus on advantage and disadvantage of PRP therapies.
کلید واژگان :Platelet Rich Plasma, Healing, Repair
ارزش ریالی : 300000 ریال
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