Association of rs2695121 variant of LXRβ gene with obesity risk in in an Iranian Population

Introduction: Several Genetic analyses have clearly shown the genetic contribution to obesity and its related phenotypes. Liver X receptor Beta (LXRβ), located in an obesity susceptible region play a pivotal role in carbohydrate and lipid metabolism, so, genetic variations in it may play a role in etiology of human obesity. The aim of this study was to explore the relationship between the LXRβ rs2695121 polymorphism and the risk of obesity and related traits. Materials and methods: The TaqMan allelic discrimination assay was used to detect the genotype of rs2695121 in LXRβ gene in 168/209 obese/overweight and 76 healthy control subjects. The difference of genotype distribution between the groups was analyzed using Chi-square test and logistic regression analysis. Univariate analyses were used to compare the levels of anthropometric and clinical variables between different genotypes. Results: The allelic frequency of LXRβ gene variant in whole population and also in studied groups was in the Hardy-Weinberg equilibrium. The genotype and allele frequencies of the investigated SNPs exhibited no significant differences between the control and the overweight/obese groups neither in the crud state nor after adjustment for age and gender (odds ratio: 1.17 (CI = 0.46–2.91), P > 0.05). However, among the clinical and metabolic parameters tested, systolic and diastolic blood pressure were associated with the genotype CT (P=0.031 and P = 0.17 respectively). Conclusion: Results of the present study suggested that LXRβ rs2695121 polymorphism may not contribute in development of obesity in an Iranian population.

Obesity, Liver X receptor-β, rs2695121, Polymorphism