Neuraminidase (NA) is the essential surface glycoprotein of the influenza virus. High- affinity
neuraminidase inhibitors have been designed that interact only with the conserved active site and binding
site residues. The neuraminidase (NA) of influenza virus is the target of anti – flu drug.for treatment of this
disease a thorough knowledge of neuraminidase protein is essential in order to produce potent drugs to
suppress this enzyme..Drug design is by QSAR and docking methods, so we need a complete knowledge of
receptor ligand, target site and binding site. This paper, using bioinformatics, Molecular Dynamics, Monte
carlo and studied binding site NA enzyme in 310K temperature and different dielectrics (1, 78.39 and
32.63) for the best drug designing. We measured the potential energy of amino acids binding to the drug.
Molecular Mechanics, Molecular Dynamic and Nanobiological have done a great assistance in drug
designing
