In this study the role of the dose level of cyclophosphamide, methotrexate, and fluorouracil in chemotherapy for breast cancer and in chemotherapy for metastatic breast cancer were investigated and the effects of TNF-α on estrogen metabolism was evaluated. There was a clear dose-response effect, indicating that CMF was useful only when given in a full or nearly full dose. Chemotherapy uses drugs to destroy cancer cells. If cancer has a high risk of returning or spreading to another part of body, it was recommended chemotherapy to decrease the chance that the cancer will recur. This was associated with a concomitant effect on the expression of detoxification enzymes COMT and NQO1 where TNF-α reduced the expression levels of these two enzymes. This may implicate a new possible explanation for inflammation associated breast cancer. Our findings indicate that it is necessary to administer combination chemotherapy at a full dose to achieve clinical benefit.
کلید واژگان :breast cancer, medicine dose, biochemistry
ارزش ریالی : 300000 ریال
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