The Effect of 8 weeks Combined exercise (aerobic - resistance) on serum IL-18 levels in obese men

INTRODUCTION IL-18 is a proinflammatory cytokine with important regulatory functions in the innate immune system and increases the production of adhesion molecules, the detection of nitric oxide synthesis. It also plays a crucial role in vascular pathology and is an index to predict cardiovascular mortality (1). As Physical activities lead to obese decrease ;doing regular exercises causes decreasing of the released inflammatory signs from fat tissue and decreases the danger of getting acute disease (2). Most studies of IL-18 have pointed decreasing effect of aerobic exercise and less pointed to the lack of its impact (3). The number of researches which have studied the effect of resistance training on obese men specially about IL-18 are few. For example Stansvold and coworkes studied the changes of IL-18 following resistant training in Syndrom Metabolic people) 4) and Kohut & Associates is a training and flexibility / resistance levels of IL-18 were examined in older adults (5). Related to the obesity and IL-18 relation ship and their subtle inflammatory mediators in causing cardio-vascular charges,and mental relations with obesity and inconstans studia antea eventus; ratio autem huius studium The Effect of 8 weeks Combined exercise (aerobic - resistance) on serum IL-18 levels in obese men. METHODS The participants of the study, were 30 obese men with a mean age (control group: 27.5 ± 5.8, the experimental group: 28.4 ± 4.9), body weight (control group: 95.5 ± 8.9 experimental group: 93.4 ± 8.3), mean height (control group: 176 ± 5, the experimental group: 175 ± 6.6) and body mass index greater than 30 . to select obese healthy people with the ability to participate in the exercises, Parkyv questionnaire (questionnaire prepared for the onset of physical activity) was used. Then randomly divided into two experimental groups (n = 15) and control (n = 15) groups. Empirical experimental group did the combined exercise program (aerobic exercise such as running on a treadmill for 20 minutes at 60-70% of maximal oxygen uptake (VO2max)) and resistance exercise with 50% of one repetition maximum (1RM) with (10 reps per move for 2 sets) for 8 weeks (three sessions per week. To calculate (1RM) the formula [weight (kg) ÷1.0278-0.0278× (number of repetitions)] values was used. Blood samples were collected in two stages, 48 hours before and after exercise for measurement of serum IL-18 levels. All variables, including age, weight, height gauge brands using SECA, weight, body fat percentage, BMI, and VO2max test device BIOSPACE In Body marking beam were measured. To determine the concentration of serum IL-18 kit made in China under license EASTBIOPHRM America was used .Descriptive statistic was used to investigate subjects demographic features ,and all variables , after testing the normality , of data distribution , Kolmogrof Smirnof used and for the itra comparison paired t test and to compare intergroup in depended t test was used. RESULTS Table 1 shows the changes of different variables between the groups. Results indicated amounts of weight, body fat percentage, BMI, VO2max and serum IL-18 combination of exercise (aerobic - resistance) in the comparison between groups (t-test) and within group (paired t-test) were significantly different (p≤0.05). Figure 2. Mean changes in serum IL-18 (pico grams per milliliter) in the experimental and control groups after eight weeks of combined exercise (aerobic - resistive) shows significant changes in inter-group comparison (p≤0.03), and compared between groups had a significant reduction (p≤0.01). Table 1. Study variabiles mutatio, scilicet de pretest ad posttest in experimentis group et control group Statistic Index group Pre test Post test P* P** mean±standard deviation mean±standard deviation Weight(Kg) Experimental 45.15±02.83 15.49±23.83 0.900 0.000** control 15.59±85.53 15.28±80.29 0.000* Fat percentage(%) Experimental 2.465±3.506 2.405±35.532 0.671 0.000** control 2.71±34.74 2.61±32.32 0.000* BMI(kg/m2) Experimental 3.198±30.404 3.203±30.478 0.090 0.000** control 3.55±31.046 3.41±29.14 0.000* VO2max ml/kg/min)) Experimental 1.33±25.56 2.824±24.76 0.236 0.012** control 4.62±26.92 1.37±30.08 0.033* IL-18(pg/ml) Experimental 55.39±268.75 47.34±259.37 0.15 0.01** control 57.86±253.15 37.01±130.32 0.03* * significant changes in comparison inter-group secundum (paired t-test) (p≤0.05), ** significant changes in comparison between group secundum (t-test) (p≤0.05). Figure 1- compares the mean change 18 IL- (pico grams per milliliter) in the experimental and control groups after 8 weeks of combined exercise (aerobic-resistance) CONCLUSION According to this study, body weight, body fat percentage, BMI and IL-18 following an 8-weeks combined exercise (aerobic - resistance) significantly declined and increased VO2max significantly increased. Confirming the present study results , in a study, after 38 weeks of diet and weight loss in obese subjects, serum IL-18 levels were significantly decreased (6). Kohut and colleagues in a study of exercise flexibility / resistance levels of IL-18 for 10 months did not change in older adults (5). Stensvold and colleagues also showed that 12 weeks of resistance training did not induce significant changes in IL-18 (4) that the findings are inconsistent. Consistent with previous studies, this study might be due to either Countercurrent intensity, duration and type of exercise depends. Mainly the aerobic traning studies pointed out to the declining effect of this exercise on serum levels of IL-18 (3). The results showed that the combination of exercise (aerobic - resistance) for 8 weeks decreased serum levels of IL-18 in the obese men.

Cmbined exercise, IL-18, obesity