Plant-based recombinant vaccines

As an alternative for traditional methods, the use of plant-based systems for production of oral vaccines has attracted great attention in recent years. Plants offer many advantages over other methods that make them excellent platforms for producing recombinant vaccines. Here, we review various aspects of this promising technology including the principles of recombinant vaccine production, plant host selection, transformation systems, strategies toward enhancing gene expression level and mechanisms involved in mucosal immunity.

antigen; genetic engineering; plant; recombinant vaccine; transformation