Introduction: The most common types of leukemia are acute myeloid leukemia (AML) with the lowest survival rate among all of the leukemias particularly in adults. The evidence has been shown that dysregulation of miRNAs expression is associated with AML. Therefore, the aim of this systematic review was to clarify the role of miR-181a expression in AML. Methods and analysis: In the present study, observational studies of the roles of miR-181a expression in patients with AML will be included. Standards and indicators test should be performed for all patients. We will search PubMed, SCOPUS and ISI Web of Science with no restriction of language. The outcomes will be reviewed for association between miR-181a level and AML progression and investigate the strength of this relationship with AML. Selection of articles and data extraction will be performed by two independent reviewers. STROBE will be used for assessment of study quality. Publication bias and data synthesis will be an assessment by funnel plots and Beggs and Egger’s tests using Stata software V.12.1.
کلید واژگان :miR-181a, Acute Myeloid Leukemia, Relationship
ارزش ریالی : 300000 ریال
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