Study of Prevalence of Thalassemia and Comparison of Hematological Indices in Types of Thalassemia in Marriage Candidate Patients in Kohgiluye & Boyerahmad Province in 2014

Background & aim: Thalassemia is an inherited autosomal recessive anemia caused by structural variations or abnormalities in globin chain synthesis. The screening of thalassemia in marriage candidates is a suitable opportunity for prevention and control of this disease. Regarding hematologic indices variations in above-mentioned patients, this study was conducted to compare the hematological indices variations in types of Thalassemia in marriage candidate patients in Kohgiluye & Boyerahmad province in 1392. Methods: In the present cross-sectional study, the results of the genetic analysis by GAP-PCR method and hematological indices including MCV, MCH, HGA2 and RBC of 111 thalassemic marriage candidates who referred to health centers, along with their demographic data was analyzed with descriptive statistics and inferential statistics [ and Pearson correlation, by the SPSS software version 17. Results: Alpha thalassemia (78/4 percent), non-alpha-beta thalassemia (9 percent) and beta thalassemia (8.1 percent) were the most frequent types, respectively. The average of hematological indices were 2/77 ± 0/75, 75/62 ± 5/58, 23/87 ± 2/40 5/61 ± 0/62 for HbA2, MCV, MCH and RBC, respectively. Alpha thalassemia patients showed higher MCV average in comparison to beta thalassemia cases. The difference of average of MCV between patients with alpha-thalassemia and patients with non-alpha/beta was not statistically significant. MCV average in Beta thalassemia was not different with both Alpha thalassemia and non-alpha/beta thalassemia. MCH and HgA2 difference between different thalassemia types was matched with MCV but RBC average difference was not significant for any types of thalassemia. There was a direct significant correlation between MCV and MCH for all types of thalassemia. MCV and MCH indices averages have inversely correlated with RBC In patients with alpha thalassemia (p =0/01). Conclusion: the difference of average blood parameters including MCV, MCH and HgA2 between beta thalassemia cases with alpha, non-alpha-beta thalassemia patients with beta thalassemia cases, and beta thalassemia with both alpha and non-alpha-beta thalassemia can be used as a predictive marker for clinical diagnosis types of thalassemia among Kohgiluye and Boyerahmad province patients.

Alpha thalassemia, Beta thalassemia, Blood indices